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Tsao, Che-Kai; Liaw, Bobby; He, Catherine; Galsky, Matthew D.; Sfakianos, John; Oh, William K.
Therapeutic Advances in Medical Oncology, 04/2017, Letnik: 9, Številka: 4Book Review, Journal Article
Renal cell cancer (RCC) continues to be among the most lethal malignancies in the USA. Introduction of anti-vascular epidermal growth factor receptor tyrosine kinase inhibitors over a decade ago resulted in improvement in disease outcomes, but further development of new therapies largely stagnated for many years. More recently, a better understanding of disease biology and treatment-resistance patterns has led to a second renaissance in drug development, with the anti-programmed cell death protein 1 immune checkpoint inhibitor, nivolumab, paving the way for additional therapies entering clinical trial testing in the treatment of RCC.
