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Scelo, Ghislaine; Wang, Zhaoming; Ye, Yuanqing; Hofmann, Jonathan N; Choi, Jiyeon; Machiela, Mitchell J; Li, Peng; Sampson, Joshua N; Abedi-Ardekani, Behnoush; Besse, Celine; Blanche, Helene; Burdette, Laurie; Chabrier, Amelie; Durand, Geoffroy; Le Calvez-Kelm, Florence; Robinot, Nivonirina; Wozniak, Magdalena B; Yeager, Meredith; Basta-Jovanovic, Gordana; Dzamic, Zoran; Foretova, Lenka; Holcatova, Ivana; Mates, Dana; Mukeriya, Anush; Rascu, Stefan; Zaridze, David; Bencko, Vladimir; Cybulski, Cezary; Fabianova, Eleonora; Lissowska, Jolanta; Lubinski, Jan; Navratilova, Marie; Rudnai, Peter; Szeszenia-Dabrowska, Neonila; Benhamou, Simone; Cancel-Tassin, Geraldine; Cussenot, Olivier; Baglietto, Laura; Khaw, Kay-Tee; Weiderpass, Elisabete; Ljungberg, Borje; Sitaram, Raviprakash T; Jordan, Susan J; Severi, Gianluca; Winship, Ingrid; Hveem, Kristian; Vatten, Lars J; Fletcher, Tony; Koppova, Kvetoslava; Larsson, Susanna C; Wolk, Alicja; Banks, Rosamonde E; Selby, Peter J; Easton, Douglas F; Pharoah, Paul; Andreotti, Gabriella; Albanes, Demetrius; Männistö, Satu; Weinstein, Stephanie; Clark, Peter E; Edwards, Todd L; Lipworth, Loren; Gapstur, Susan M; Stevens, Victoria L; Carol, Hallie; Freedman, Matthew L; Pomerantz, Mark M; Kraft, Peter; Preston, Mark A; Wilson, Kathryn M; Michael Gaziano, J; Sesso, Howard D; Freedman, Neal D; Huang, Wen-Yi; Anema, John G; Kahnoski, Richard J; Lane, Brian R; Noyes, Sabrina L; Petillo, David; Teh, Bin Tean; Peters, Ulrike; White, Emily; Anderson, Garnet L; Johnson, Lisa; Buring, Julie; Chow, Wong-Ho; Moore, Lee E; Wood, Christopher; Eisen, Timothy; Henrion, Marc; Larkin, James; Leibovich, Bradley C; Choueiri, Toni K; Mark Lathrop, G; Rothman, Nathaniel; Deleuze, Jean-Francois; Parker, Alexander S; Wu, Xifeng; Brennan, Paul; Chanock, Stephen J
Nature communications, 06/2017, Letnik: 8, Številka: 1Journal Article
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10 ), 3p22.1 (rs67311347, P=2.5 × 10 ), 3q26.2 (rs10936602, P=8.8 × 10 ), 8p21.3 (rs2241261, P=5.8 × 10 ), 10q24.33-q25.1 (rs11813268, P=3.9 × 10 ), 11q22.3 (rs74911261, P=2.1 × 10 ) and 14q24.2 (rs4903064, P=2.2 × 10 ). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
