E-viri
Recenzirano
Odprti dostop
-
Xu, Qingyu; Streuer, Alexander; Jann, Johann-Christoph; Altrock, Eva; Schmitt, Nanni; Flach, Johanna; Sens-Albert, Carla; Rapp, Felicitas; Wolf, Julia; Nowak, Verena; Weimer, Nadine; Obländer, Julia; Palme, Iris; Kuzina, Mariia; Jawhar, Ahmed; Darwich, Ali; Weis, Cleo-Aron; Marx, Alexander; Wuchter, Patrick; Costina, Victor; Jäger, Evelyn; Sperk, Elena; Neumaier, Michael; Fabarius, Alice; Metzgeroth, Georgia; Nolte, Florian; Steiner, Laurenz; Levkin, Pavel A; Jawhar, Mohamad; Hofmann, Wolf-Karsten; Riabov, Vladimir; Nowak, Daniel
Nature communications, 03/2023, Letnik: 14, Številka: 1Journal Article
Limited response rates and frequent relapses during standard of care with hypomethylating agents in myelodysplastic neoplasms (MN) require urgent improvement of this treatment indication. Here, by combining 5-azacytidine (5-AZA) with the pan-lysyl oxidase inhibitor PXS-5505, we demonstrate superior restoration of erythroid differentiation in hematopoietic stem and progenitor cells (HSPCs) of MN patients in 20/31 cases (65%) versus 9/31 cases (29%) treated with 5-AZA alone. This effect requires direct contact of HSPCs with bone marrow stroma components and is dependent on integrin signaling. We further confirm these results in vivo using a bone marrow niche-dependent MN xenograft model in female NSG mice, in which we additionally demonstrate an enforced reduction of dominant clones as well as significant attenuation of disease expansion and normalization of spleen sizes. Overall, these results lay out a strong pre-clinical rationale for efficacy of combination treatment of 5-AZA with PXS-5505 especially for anemic MN.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.