E-viri
Recenzirano
Odprti dostop
-
Laso-García, Fernando; Casado-Fernández, Laura; Piniella, Dolores; Gómez-de Frutos, Mari Carmen; Arizaga-Echebarria, Jone Karmele; Pérez-Mato, María; Alonso-López, Elisa; Otero-Ortega, Laura; Bravo, Susana Belén; Chantada-Vázquez, María del Pilar; Avendaño-Ortiz, José; López-Collazo, Eduardo; Lumbreras-Herrera, María Isabel; Gámez-Pozo, Angelo; Fuentes, Blanca; Díez-Tejedor, Exuperio; Gutiérrez-Fernández, María; Alonso de Leciñana, María
Molecular therapy. Nucleic acids, 06/2023, Letnik: 32Journal Article
Circulating extracellular vesicles (EVs) are proposed to participate in enhancing pathways of recovery after stroke through paracrine signaling. To verify this hypothesis in a proof-of-concept study, blood-derived allogenic EVs from rats and xenogenic EVs from humans who experienced spontaneous good recovery after an intracerebral hemorrhage (ICH) were administered intravenously to rats at 24 h after a subcortical ICH. At 28 days, both treatments improved the motor function assessment scales score, showed greater fiber preservation in the perilesional zone (diffusion tensor-fractional anisotropy MRI), increased immunofluorescence markers of myelin (MOG), and decreased astrocyte markers (GFAP) compared with controls. Comparison of the protein cargo of circulating EVs at 28 days from animals with good vs. poor recovery showed down-expression of immune system activation pathways (CO4, KLKB1, PROC, FA9, and C1QA) and of restorative processes such as axon guidance (RAC1), myelination (MBP), and synaptic vesicle trafficking (SYN1), which is in line with better tissue preservation. Up-expression of PCSK9 (neuron differentiation) in xenogenic EVs-treated animals suggests enhancement of repair pathways. In conclusion, the administration of blood-derived EVs improved recovery after ICH. These findings open a new and promising opportunity for further development of restorative therapies to improve the outcomes after an ICH. Display omitted Treatment with blood-derived extracellular vesicles (EVs) enhance brain protection and repair post-ICH and improve functional recovery. The administration of allogeneic or xenogenic blood-derived EVs, regardless of origin, is safe. Proteins in EVs are involved in biological pathways of neural protection and repair.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.