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Casalegno Garduño, Rosaely; Däbritz, Jan
Frontiers in immunology, 10/2021, Letnik: 12Journal Article
CD8 T cells are involved in the pathogenesis of inflammatory bowel disease (IBD), a complex multifactorial chronic disease. Here, we present an overview of the current research with the controversial findings of CD8 T cell subsets and discuss some possible perspectives on their therapeutic value in IBD. Studies on the role of CD8 T cells in IBD have contradictory outcomes, which might be related to the heterogeneity of the cells. Recent data suggest that cytotoxic CD8 T cells (Tc1) and interleukin (IL) 17-producing CD8 (Tc17) cells contribute to the pathogenesis of IBD. Moreover, subsets of regulatory CD8 T cells are abundant at sites of inflammation and can exhibit pro-inflammatory features. Some subsets of tissue resident memory CD8 T cells (Trm) might be immunosuppressant, whereas others might be pro-inflammatory. Lastly, exhausted T cells might indicate a positive outcome for patients. The function and plasticity of different subsets of CD8 T cells in health and IBD remain to be further investigated in a challenging field due to the limited availability of mucosal samples and adequate controls.
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in: SICRIS
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