Abstract Lack of dystrophin results in skeletal muscle dystrophy and dilated cardiomyopathy in humans and animal models. To achieve a basic understanding of the natural development of cardiomyopathy in different dystrophinopathy mouse models, left and right ventricular heart function was assessed at different ages in three dystrophinopathy mouse models ( mdx , mdx / utrn+/− model and mdx / utrn−/− ) using magnetic resonance imaging. Left ventricular function was significantly decreased, already at 2 months in the most severely affected mdx / utrn−/− mice. Furthermore, whereas heart function was stable in wild-type mice over time, both mdx and mdx / utrn+/− showed a clear decrease at 10 months of age, most prominently in the right ventricle. Therefore magnetic resonance imaging is an adequate technique to determine heart function in dystrophinopathy mouse models and can be used to assess the effect of potential therapies.