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Wolf, Erika J; Logue, Mark W; Hayes, Jasmeet P; Sadeh, Naomi; Schichman, Steven A; Stone, Annjanette; Salat, David H; Milberg, William; McGlinchey, Regina; Miller, Mark W
Psychoneuroendocrinology, 01/2016, Letnik: 63Journal Article
Highlights • Cellular age can be indexed by DNA methylation and may be advanced relative to chronological age due to environmental factors. • Among 281 Iraq/Afghanistan veterans, we found PTSD severity to be associated with accelerated DNA methylation age. • Accelerated DNA methylation age was also associated with reduced neural integrity in the genu of the corpus callosum. • Accelerated DNA methylation age was indirectly linked to poorer working memory via reduced integrity of the genu. • This highlights the clinical significance of PTSD-related accelerated aging with respect to neural integrity and cognition.
