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Yagishita, Mizuki; Tsuboi, Hiroto; Kuroda, Yuki; Sawabe, Tomonori; Kawashima, Akira; Kawashima, Fumina; Uematsu, Nana; Sato, Ryota; Nishiyama, Taihei; Terasaki, Mayu; Toko, Hirofumi; Honda, Fumika; Ohyama, Ayako; Abe, Saori; Kitada, Ayako; Miki, Haruka; Hagiwara, Shinya; Kondo, Yuya; Sumida, Takayuki; Matsumoto, Isao
Scientific reports, 12/2022, Letnik: 12, Številka: 1Journal Article
Recent studies have suggested that the clinical features of elderly-onset adult-onset Still's disease (AOSD) differ from those of young and middle-aged-onset patients, whereas the details remain unclear, and cytokine profiles of elderly-onset AOSD have not been reported. To clarify the clinical features and cytokine profiles of elderly-onset AOSD, we examined patients with AOSD who developed the disease between January 2006 and September 2021. We divided the patients into the young and middle-aged-onset group (aged < 65 years) and the elderly-onset group (aged ≥ 65 years) and compared the groups in terms of patient characteristics, clinical symptoms, laboratory findings including serum interleukin (IL)-6 and IL-18, treatment, and prognosis. A total of 48 patients were examined (10 in the elderly-onset group). In the elderly-onset group, atypical rash was significantly more frequent, typical rash and splenomegaly were significantly less frequent, white blood cell count and neutrophil ratio were significantly higher and serum IL-6 levels were significantly lower. Serum IL-6 showed a significantly negative correlation with age at onset. Treatment and relapse were comparable between the 2 groups, whereas infections were significantly more frequent in the elderly-onset group. The clinical features and cytokine profiles of elderly-onset AOSD might differ from those of young and middle-aged-onset AOSD.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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