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Zhou, Yueying; Xin, Xiaonan; Wang, Lichao; Wang, Binsheng; Chen, Li; Liu, Ousheng; Rowe, David W; Xu, Ming
npj Regenerative medicine, 06/2021, Letnik: 6, Številka: 1Journal Article
The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.
