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Verity, Robert; Aydemir, Ozkan; Brazeau, Nicholas F; Watson, Oliver J; Hathaway, Nicholas J; Mwandagalirwa, Melchior Kashamuka; Marsh, Patrick W; Thwai, Kyaw; Fulton, Travis; Denton, Madeline; Morgan, Andrew P; Parr, Jonathan B; Tumwebaze, Patrick K; Conrad, Melissa; Rosenthal, Philip J; Ishengoma, Deus S; Ngondi, Jeremiah; Gutman, Julie; Mulenga, Modest; Norris, Douglas E; Moss, William J; Mensah, Benedicta A; Myers-Hansen, James L; Ghansah, Anita; Tshefu, Antoinette K; Ghani, Azra C; Meshnick, Steven R; Bailey, Jeffrey A; Juliano, Jonathan J
Nature communications, 04/2020, Letnik: 11, Številka: 1Journal Article
The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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