E-viri
Recenzirano
Odprti dostop
-
Feng, Allan; Yang, Emily Y; Moore, Andrew Reese; Dhingra, Shaurya; Chang, Sarah Esther; Yin, Xihui; Pi, Ruoxi; Mack, Elisabeth Km; Völkel, Sara; Geßner, Reinhard; Gündisch, Margrit; Neubauer, Andreas; Renz, Harald; Tsiodras, Sotirios; Fragkou, Paraskevi C; Asuni, Adijat A; Levitt, Joseph E; Wilson, Jennifer G; Leong, Michelle; Lumb, Jennifer H; Mao, Rong; Pinedo, Kassandra; Roque, Jonasel; Richards, Christopher M; Stabile, Mikayla; Swaminathan, Gayathri; Salagianni, Maria L; Triantafyllia, Vasiliki; Bertrams, Wilhelm; Blish, Catherine A; Carette, Jan E; Frankovich, Jennifer; Meffre, Eric; Nadeau, Kari Christine; Singh, Upinder; Wang, Taia T; Luning Prak, Eline T; Herold, Susanne; Andreakos, Evangelos; Schmeck, Bernd; Skevaki, Chrysanthi; Rogers, Angela J; Utz, Paul J
JCI insight, 02/2023, Letnik: 8, Številka: 3Journal Article
The widespread presence of autoantibodies in acute infection with SARS-CoV-2 is increasingly recognized, but the prevalence of autoantibodies in non-SARS-CoV-2 infections and critical illness has not yet been reported. We profiled IgG autoantibodies in 267 patients from 5 independent cohorts with non-SARS-CoV-2 viral, bacterial, and noninfectious critical illness. Serum samples were screened using Luminex arrays that included 58 cytokines and 55 autoantigens, many of which are associated with connective tissue diseases (CTDs). Samples positive for anti-cytokine antibodies were tested for receptor blocking activity using cell-based functional assays. Anti-cytokine antibodies were identified in > 50% of patients across all 5 acutely ill cohorts. In critically ill patients, anti-cytokine antibodies were far more common in infected versus uninfected patients. In cell-based functional assays, 11 of 39 samples positive for select anti-cytokine antibodies displayed receptor blocking activity against surface receptors for Type I IFN, GM-CSF, and IL-6. Autoantibodies against CTD-associated autoantigens were also commonly observed, including newly detected antibodies that emerged in longitudinal samples. These findings demonstrate that anti-cytokine and autoantibodies are common across different viral and nonviral infections and range in severity of illness.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.