Most of these disorders are difficult to treat and can be life threatening. ...NMJ maintenance plays a key role in weakened muscle function during aging (Hunter et al., 2016). The authors found an enrichment of known and novel genes that are part of different networks such as diacylglycerol and phosphatidylinositol signaling or extracellular matrix components, thus expanding the group of molecular players involved in NMJ development. ...Spendiff et al. treated CMS model mice with a genetic defect in the AGRN gene using a small agrin compound, which restored post-synaptic structure and improved muscle strength through normalization of muscle fiber composition and the prevention of atrophy. Coppedè et al. investigated blood and thymoma tissues from 69 TAMG patients and studied the methylation pattern of tumor suppressor and DNA repair genes but did not observe any differences in the methylation between thymoma tissue and unaffected thymus tissue or any correlation between clinic, methylation and histopathology.