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Jing, Lichen; Wu, Xia; Krist, Maxwell P; Hsiang, Tien-Ying; Campbell, Victoria L; McClurkan, Christopher L; Favors, Sydney M; Hemingway, Lawrence A; Godornes, Charmie; Tong, Denise Q; Selke, Stacy; LeClair, Angela C; Pyo, Chu-Woo; Geraghty, Daniel E; Laing, Kerry J; Wald, Anna; Gale, Jr, Michael; Koelle, David M
JCI insight, 03/2022, Letnik: 7, Številka: 6Journal Article
SARS-CoV-2 provokes a robust T cell response. Peptide-based studies exclude antigen processing and presentation biology, which may influence T cell detection studies. To focus on responses to whole virus and complex antigens, we used intact SARS-CoV-2 and full-length proteins with DCs to activate CD8 and CD4 T cells from convalescent people. T cell receptor (TCR) sequencing showed partial repertoire preservation after expansion. Resultant CD8 T cells recognize SARS-CoV-2-infected respiratory tract cells, and CD4 T cells detect inactivated whole viral antigen. Specificity scans with proteome-covering protein/peptide arrays show that CD8 T cells are oligospecific per subject and that CD4 T cell breadth is higher. Some CD4 T cell lines enriched using SARS-CoV-2 cross-recognize whole seasonal coronavirus (sCoV) antigens, with protein, peptide, and HLA restriction validation. Conversely, recognition of some epitopes is eliminated for SARS-CoV-2 variants, including spike (S) epitopes in the Alpha, Beta, Gamma, and Delta variant lineages.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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