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  • ChAdOx1 and MVA based vacci...
    Alharbi, Naif Khalaf; Padron-Regalado, Eriko; Thompson, Craig P; Kupke, Alexandra; Wells, Daniel; Sloan, Megan A; Grehan, Keith; Temperton, Nigel; Lambe, Teresa; Warimwe, George; Becker, Stephan; Hill, Adrian V.S; Gilbert, Sarah C

    Vaccine, 06/2017, Letnik: 35, Številka: 30
    Journal Article

    Highlights • Inserting tPA leader sequence enhanced humoral responses of ChAdOx1 MERS. • ChAdOx1 MERS elicited cellular immunity and neutralising antibodies. • ChAdOx1 MERS responses were boosted by MVA MERS. • Immunogenicity of a single dose of ChAdOx1 MERS was equivalent to 2 doses of MVA MERS. • In MVA, F11 promoter enhanced cellular, but not humoral, immunogenicity, comparing to mH5 promoter.