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Myers, Samuel A; Wright, Jason; Peckner, Ryan; Kalish, Brian T; Zhang, Feng; Carr, Steven A
Nature methods, 06/2018, Letnik: 15, Številka: 6Journal Article
Regulation of gene expression is primarily controlled by changes in the proteins that occupy genes' regulatory elements. We developed genomic locus proteomics (GLoPro), in which we combine CRISPR-based genome targeting, proximity labeling, and quantitative proteomics to discover proteins associated with a specific genomic locus in native cellular contexts.
