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Zhang, Jia-Yuan; Hamey, Fiona; Trzupek, Dominik; Mickunas, Marius; Lee, Mercede; Godfrey, Leila; Yang, Jennie H M; Pekalski, Marcin L; Kennet, Jane; Waldron-Lynch, Frank; Evans, Mark L; Tree, Timothy I M; Wicker, Linda S; Todd, John A; Ferreira, Ricardo C
Nature communications, 11/2022, Letnik: 13, Številka: 1Journal Article
Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the effects of interval administration of low-dose recombinant IL-2 (iLD-IL-2) in type 1 diabetes using high-resolution single-cell multiomics and flow cytometry on longitudinally-collected peripheral blood samples. Our results confirm that iLD-IL-2 selectively expands thymic-derived FOXP3 HELIOS regulatory T cells and CD56 NK cells, and show that the treatment reduces the frequency of IL-21-producing CD4 T cells and of two innate-like mucosal-associated invariant T and V V CD8 T cell subsets. The cellular changes induced by iLD-IL-2 associate with an anti-inflammatory gene expression signature, which remains detectable in all T and NK cell subsets analysed one month after treatment. These findings warrant investigations into the potential longer-term clinical benefits of iLD-IL-2 in immunotherapy.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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