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Furuzawa-Carballeda, Janette; Zuñiga, Joaquín; Hernández-Zaragoza, Diana I; Barquera, Rodrigo; Marques-García, Eduardo; Jiménez-Alvarez, Luis; Cruz-Lagunas, Alfredo; Ramírez, Gustavo; Regino, Nora E; Espinosa-Soto, Ramón; Yunis, Edmond J; Romero-Hernández, Fernanda; Azamar-Llamas, Daniel; Coss-Adame, Enrique; Valdovinos, Miguel A; Torres-Landa, Samuel; Palacios-Ramírez, Axel; Breña, Blanca; Alejandro-Medrano, Edgar; Hernández-Ávila, Axel; Granados, Julio; Torres-Villalobos, Gonzalo
PloS one, 08/2018, Letnik: 13, Številka: 8Journal Article
Idiopathic achalasia is a relatively infrequent esophageal motor disorder for which major histocompatibility complex (MHC) genes are well-identified risk factors. However, no information about HLA-achalasia susceptibility in Mexicans has previously been reported. We studied a group of 91 patients diagnosed with achalasia and 234 healthy controls with Mexican admixed ancestry. HLA alleles and conserved extended haplotypes were analyzed using high-resolution HLA typing based on Sanger and next-generation sequencing technologies. Admixture estimates were determined using HLA-B and short tandem repeats. Results were analyzed by non-parametric statistical analysis and Bonferroni correction. P-values < 0.05 were considered significant. Patients with achalasia had 56.7% Native American genes, 24.7% European genes, 16.5% African genes and 2.0% Asian genes, which was comparable with the estimates in the controls. Significant increases in the frequencies of alleles DRB1*14:54 and DQB1*05:03 and the extended haplotypes DRB1*14:54-DQB1*05:03 and DRB1*11:01-DQB1*03:01, even after Bonferroni correction (pC<0.05), were found in the achalasia group compared to those in the controls. Concluding, the HLA class II alleles HLA-DRB1*14:54:01 and DQB1*05:03:01 and the extended haplotype are risk factors for achalasia in mixed-ancestry Mexican individuals. These results also suggest that the HLA-DRB1*14:54-DQB1*05:03 haplotype was introduced by admixture with European and/or Asian populations.
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