E-viri
Recenzirano
Odprti dostop
-
Purves, Kirstin L; Coleman, Jonathan R I; Meier, Sandra M; Rayner, Christopher; Davis, Katrina A S; Cheesman, Rosa; Bækvad-Hansen, Marie; Børglum, Anders D; Wan Cho, Shing; Jürgen Deckert, J; Gaspar, Héléna A; Bybjerg-Grauholm, Jonas; Hettema, John M; Hotopf, Matthew; Hougaard, David; Hübel, Christopher; Kan, Carol; McIntosh, Andrew M; Mors, Ole; Bo Mortensen, Preben; Nordentoft, Merete; Werge, Thomas; Nicodemus, Kristin K; Mattheisen, Manuel; Breen, Gerome; Eley, Thalia C
Molecular psychiatry, 12/2020, Letnik: 25, Številka: 12Journal Article
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (n = 25 453, n = 58 113) and an additional analysis of Current Anxiety Symptoms (n = 19 012, n = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.