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Rong, Zhuo-Xian; Li, Zhi; He, Jun-Ju; Liu, Li-Yu; Ren, Xin-Xin; Gao, Jie; Mu, Yun; Guan, Yi-Di; Duan, Yu-Mei; Zhang, Xiu-Ping; Zhang, De-Xiang; Li, Nan; Deng, Yue-Zhen; Sun, Lun-Quan
Frontiers in oncology, 05/2019, Letnik: 9Journal Article
Intrahepatic cholangiocarcinoma (ICC) ranks as the second most malignant type of primary liver cancer with a high degree of incidence and a very poor prognosis. Fat mass and obesity-associated protein (FTO) functions as an eraser of the RNA m A modification, but its roles in ICC tumorigenesis and development remain unknown. We showed here that the protein level of FTO was downregulated in clinical ICC samples and cell lines and that FTO expression was inversely correlated with the expression of CA19-9 and micro-vessel density (MVD). A Kaplan-Meier survival analysis showed that a low expression of predicted poor prognosis in ICC. , decreased endogenous expression of obviously reduced apoptosis of ICC cells. Moreover, suppressed the anchorage-independent growth and mobility of ICC cells. Through mining the database, FTO was found to regulate the integrin signaling pathway, inflammation signaling pathway, epidermal growth factor receptor (EGFR) signaling pathway, angiogenesis, and the pyrimidine metabolism pathway. RNA decay assay showed that oncogene mRNA stability was impaired by FTO. In addition, the overexpression of FTO suppressed tumor growth . In conclusion, our study demonstrated the critical roles of FTO in ICC.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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