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Wang, Xuehai; Nissen, Michael; Gracias, Deanne; Kusakabe, Manabu; Simkin, Guillermo; Jiang, Aixiang; Duns, Gerben; Sarkozy, Clementine; Hilton, Laura; Chavez, Elizabeth A; Segat, Gabriela C; Wong, Rachel; Kim, Jubin; Aoki, Tomohiro; Islam, Rashedul; May, Christina; Hung, Stacy; Tyshchenko, Kate; Brinkman, Ryan R; Hirst, Martin; Karsan, Aly; Freeman, Ciara; Sehn, Laurie H; Morin, Ryan D; Roth, Andrew J; Savage, Kerry J; Craig, Jeffrey W; Shah, Sohrab P; Steidl, Christian; Scott, David W; Weng, Andrew P
Nature communications, 11/2022, Letnik: 13, Številka: 1Journal Article
Follicular lymphoma (FL) is an indolent cancer of mature B-cells but with ongoing risk of transformation to more aggressive histology over time. Recurrent mutations associated with transformation have been identified; however, prognostic features that can be discerned at diagnosis could be clinically useful. We present here comprehensive profiling of both tumor and immune compartments in 155 diagnostic FL biopsies at single-cell resolution by mass cytometry. This revealed a diversity of phenotypes but included two recurrent patterns, one which closely resembles germinal center B-cells (GCB) and another which appears more related to memory B-cells (MB). GCB-type tumors are enriched for EZH2, TNFRSF14, and MEF2B mutations, while MB-type tumors contain increased follicular helper T-cells. MB-type and intratumoral phenotypic diversity are independently associated with increased risk of transformation, supporting biological relevance of these features. Notably, a reduced 26-marker panel retains sufficient information to allow phenotypic profiling of future cohorts by conventional flow cytometry.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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