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Kiu, Raymond; Caim, Shabhonam; Alexander, Sarah; Pachori, Purnima; Hall, Lindsay J
Frontiers in microbiology, 12/2017, Letnik: 8Journal Article
is an important cause of animal and human infections, however information about the genetic makeup of this pathogenic bacterium is currently limited. In this study, we sought to understand and characterise the genomic variation, pangenomic diversity, and key virulence traits of 56 strains which included 51 public, and 5 newly sequenced and annotated genomes using Whole Genome Sequencing. Our investigation revealed that has an "open" pangenome comprising 11667 genes and 12.6% of core genes, identified as the most divergent single-species Gram-positive bacterial pangenome currently reported. Our computational analyses also defined phylogeny (16S rRNA gene) in relation to some 25 species, with and determined to be the closest relatives. Profiling virulence-associated factors confirmed presence of well-characterised -associated exotoxins genes including α-toxin ( ), enterotoxin ( ), and Perfringolysin O ( or ), although interestingly there did not appear to be a close correlation with encoded toxin type and disease phenotype. Furthermore, genomic analysis indicated significant horizontal gene transfer events as defined by presence of prophage genomes, and notably absence of CRISPR defence systems in >70% (40/56) of the strains. In relation to antimicrobial resistance mechanisms, tetracycline resistance genes ( ) and anti-defensins genes ( ) were consistently detected ( : 75%; : 100%). However, pre-antibiotic era strain genomes did not encode for , thus implying antimicrobial selective pressures in evolutionary history over the past 80 years. This study provides new genomic understanding of this genetically divergent multi-host bacterium, and further expands our knowledge on this medically and veterinary important pathogen.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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