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Ai, Youwei; Yan, Bo; Wang, Xiaodong
Molecular & cellular oncology, 03/2021, Letnik: 8, Številka: 2Journal Article
Our recent study showed that two oxidoreductases - NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) - transfer electrons to oxygen to generate hydrogen peroxide (H 2 O 2 ). H 2 O 2 then reacts with ferrous iron, generating hydroxyl radicals that cause peroxidation of polyunsaturated-fatty-acid chains of membrane phospholipids, resulting in plasma membrane rupture and ferroptosis.
