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Dawson, Ted M.; Dawson, Valina L.
Movement disorders, 2010, 2010-00-00, 2010-01-00, 20100101, Letnik: 25, Številka: S1Journal Article, Conference Proceeding
Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. © 2010 Movement Disorder Society
