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Yu, Bo; Dong, Xiao; Gravina, Silvia; Kartal, Önder; Schimmel, Timothy; Cohen, Jacques; Tortoriello, Drew; Zody, Raifa; Hawkins, R. David; Vijg, Jan
Stem cell reports, 07/2017, Letnik: 9, Številka: 1Journal Article
The establishment of DNA methylation patterns in oocytes is a highly dynamic process marking gene-regulatory events during fertilization, embryonic development, and adulthood. However, after epigenetic reprogramming in primordial germ cells, how and when DNA methylation is re-established in developing human oocytes remains to be characterized. Here, using single-cell whole-genome bisulfite sequencing, we describe DNA methylation patterns in three different maturation stages of human oocytes. We found that while broad-scale patterns of CpG methylation have been largely established by the immature germinal vesicle stage, localized changes continue into later development. Non-CpG methylation, on the other hand, undergoes a large-scale, generalized remodeling through the final stage of maturation, with the net overall result being the accumulation of methylation as oocytes mature. The role of the genome-wide, non-CpG methylation remodeling in the final stage of oocyte maturation deserves further investigation. •Broad-scale CpG methylation is largely stable during oocyte maturation•Non-CpG methylation accumulates as oocytes mature•Non-CpG methylation changes are genome wide CpG methylation is established globally in adult immature oocytes and remains stable during maturation. Non-CpG methylation undergoes a genome-wide, generalized remodeling through the final stage of maturation, with the net overall result being accumulation of methylation as oocytes mature.
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