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Socié, Gérard; Barba, Pere; Barlev, Arie; Sanz, Jaime; García-Cadenas, Irene; Chevallier, Patrice; Fagioli, Franca; Guzman-Becerra, Norma; Kumar, Deepali; Ljungman, Per; Pigneux, Arnaud; Sadetsky, Natalia; Yáñez San Segundo, Lucrecia; Shadman, Mazyar; Storek, Jan; Thirumalai, Dhanalakshmi; Xing, Baodong; Mohty, Mohamad
Bone marrow transplantation (Basingstoke), 01/2024, Letnik: 59, Številka: 1Journal Article
Epstein-Barr virus-positive (EBV ) post-transplant lymphoproliferative disease (PTLD) is an ultra-rare and aggressive condition that may occur following allogeneic hematopoietic cell transplant (HCT) due to immunosuppression. Approximately half of EBV PTLD cases are relapsed or refractory (R/R) to initial rituximab-containing therapy. There are limited treatment options and no standard of care for patients with R/R EBV PTLD, and little is known about their treatment history and outcomes. We performed a multinational, multicenter, retrospective chart review of patients with R/R EBV PTLD following HCT to describe patients' demographic and disease characteristics, treatment history, and overall survival (OS) from rituximab failure. Among 81 patients who received initial treatment with rituximab as monotherapy (84.0%) or in combination with chemotherapy (16.0%), median time from HCT to PTLD diagnosis was 3.0 months and median OS was 0.7 months. Thirty-six patients received a subsequent line of treatment. The most frequent causes of death were PTLD (56.8%), graft-versus-host disease (13.5%) and treatment-related mortality (10.8%). In multivariate analysis, early PTLD onset and lack of response to initial treatment were associated with mortality. This real-world study demonstrates that the prognosis of patients with R/R EBV PTLD following HCT remains poor, highlighting the urgent unmet medical need in this population.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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