E-viri
Recenzirano
Odprti dostop
-
Ma, Xiao-Ru; Zhu, Xudong; Xiao, Yujie; Gu, Hui-Min; Zheng, Shuang-Shuang; Li, Liang; Wang, Fan; Dong, Zhao-Jun; Wang, Di-Xian; Wu, Yang; Yang, Chenyu; Jiang, Wenhong; Yao, Ke; Yin, Yue; Zhang, Yang; Peng, Chao; Gao, Lixia; Meng, Zhuoxian; Hu, Zeping; Liu, Chong; Li, Li; Chen, Hou-Zao; Shu, Yousheng; Ju, Zhenyu; Zhao, Jing-Wei
Nature communications, 03/2022, Letnik: 13, Številka: 1Journal Article
The age-dependent decline in remyelination potential of the central nervous system during ageing is associated with a declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). The molecular players that can enhance OPC differentiation or rejuvenate OPCs are unclear. Here we show that, in mouse OPCs, nuclear entry of SIRT2 is impaired and NAD levels are reduced during ageing. When we supplement β-nicotinamide mononucleotide (β-NMN), an NAD precursor, nuclear entry of SIRT2 in OPCs, OPC differentiation, and remyelination were rescued in aged animals. We show that the effects on myelination are mediated via the NAD -SIRT2-H3K18Ac-ID4 axis, and SIRT2 is required for rejuvenating OPCs. Our results show that SIRT2 and NAD levels rescue the aged OPC differentiation potential to levels comparable to young age, providing potential targets to enhance remyelination during ageing.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.