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Ekiert, Damian C.; Friesen, Robert H. E.; Bhabha, Gira; Kwaks, Ted; Jongeneelen, Mandy; Yu, Wenli; Ophorst, Carla; Cox, Freek; Korse, Hans J.W.M.; Brandenburg, Boerries; Vogels, Ronald; Brakenhoff, Just P.J.; Kompier, Ronald; Koldijk, Martin H.; Cornelissen, Lisette A.H.M.; Poon, Leo L. M.; Peiris, Malik; Koudstaal, Wouter; Wilson, Ian A.; Goudsmit, Jaap
Science (American Association for the Advancement of Science), 08/2011, Letnik: 333, Številka: 6044Journal Article
Current flu vaccines provide only limited coverage against seasonal strains of influenza viruses. The identification of V H 1-69 antibodies that broadly neutralize almost all influenza A group 1 viruses constituted a breakthrough in the influenza field. Here, we report the isolation and characterization of a human monoclonal antibody CR8020 with broad neutralizing activity against most group 2 viruses, including H3N2 and H7N7, which cause severe human infection. The crystal structure of Fab CR8020 with the 1968 pandemic H3 hemagglutinin (HA) reveals a highly conserved epitope in the HA stalk distinct from the epitope recognized by the V H 1-69 group 1 antibodies. Thus, a cocktail of two antibodies may be sufficient to neutralize most influenza A subtypes and, hence, enable development of a universal flu vaccine and broad-spectrum antibody therapies.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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