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García-Romero, N; Palacín-Aliana, I; Madurga, R; Carrión-Navarro, J; Esteban-Rubio, S; Jiménez, B; Collazo, A; Pérez-Rodríguez, F; Ortiz de Mendivil, A; Fernández-Carballal, C; García-Duque, S; Diamantopoulos-Fernández, J; Belda-Iniesta, C; Prat-Acín, R; Sánchez-Gómez, P; Calvo, E; Ayuso-Sacido, A
BMC medicine, 06/2020, Letnik: 18, Številka: 1Journal Article
Glioblastoma (GBM) is one of the most aggressive and vascularized brain tumors in adults, with a median survival of 20.9 months. In newly diagnosed and recurrent GBM, bevacizumab demonstrated an increase in progression-free survival, but not in overall survival. We conducted an in silico analysis of VEGF expression, in a cohort of 1082 glioma patients. Then, to determine whether appropriate bevacizumab dose adjustment could increase the anti-angiogenic response, we used in vitro and in vivo GBM models. Additionally, we analyzed VEGFA expression in tissue, serum, and plasma in a cohort of GBM patients before and during bevacizumab treatment. We identified that 20% of primary GBM did not express VEGFA suggesting that these patients would probably not respond to bevacizumab therapy as we proved in vitro and in vivo. We found that a specific dose of bevacizumab calculated based on VEGFA expression levels increases the response to treatment in cell culture and serum samples from mice bearing GBM tumors. Additionally, in a cohort of GBM patients, we observed a correlation of VEGFA levels in serum, but not in plasma, with bevacizumab treatment performance. Our data suggest that bevacizumab dose adjustment could improve clinical outcomes in Glioblastoma treatment.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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