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Paul, Tanja; Ledderose, Stephan; Bartsch, Harald; Sun, Na; Soliman, Sarah; Märkl, Bruno; Ruf, Viktoria; Herms, Jochen; Stern, Marcel; Keppler, Oliver T; Delbridge, Claire; Müller, Susanna; Piontek, Guido; Kimoto, Yuki Schneider; Schreiber, Franziska; Williams, Tracy Ann; Neumann, Jens; Knösel, Thomas; Schulz, Heiko; Spallek, Ria; Graw, Matthias; Kirchner, Thomas; Walch, Axel; Rudelius, Martina
Nature communications, 03/2022, Letnik: 13, Številka: 1Journal Article
Progressive respiratory failure and hyperinflammatory response is the primary cause of death in the coronavirus disease 2019 (COVID-19) pandemic. Despite mounting evidence of disruption of the hypothalamus-pituitary-adrenal axis in COVID-19, relatively little is known about the tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to adrenal glands and associated changes. Here we demonstrate adrenal viral tropism and replication in COVID-19 patients. Adrenal glands showed inflammation accompanied by inflammatory cell death. Histopathologic analysis revealed widespread microthrombosis and severe adrenal injury. In addition, activation of the glycerophospholipid metabolism and reduction of cortisone intensities were characteristic for COVID-19 specimens. In conclusion, our autopsy series suggests that SARS-CoV-2 facilitates the induction of adrenalitis. Given the central role of adrenal glands in immunoregulation and taking into account the significant adrenal injury observed, monitoring of developing adrenal insufficiency might be essential in acute SARS-CoV-2 infection and during recovery.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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