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Quiralte, Miguel; Barquín, Arantzazu; Yagüe-Fernández, Mónica; Navarro, Paloma; Grazioso, Tatiana P; Sevillano-Fernández, Elena; Rodriguez-Moreno, Juan F; Balarezo-Saldivar, Alejandra; Peinado, Héctor; Izquierdo, Elena; Millán, Carlos; López-Carrasco, Irene; Prieto, Mario; Madurga, Rodrigo; Fernández-Miranda, Ismael; Ruiz-Llorente, Sergio; García-Donas, Jesús
The Journal of clinical investigation, 05/2024, Letnik: 134, Številka: 10Journal Article
Cancer-derived small extracellular vesicles (sEVs) are capable of modifying the tumor microenvironment and promoting tumor progression. Ovarian cancer (OvCa) is a lethal malignancy that preferentially spreads through the abdominal cavity. Thus, the secretion of such vesicles into the peritoneal fluid could be a determinant factor in the dissemination and behavior of this disease. We designed a prospective observational study to assess the impact of peritoneal fluid-derived sEVs (PFD-sEVs) in OvCa clinical outcome. For this purpose, 2 patient cohorts were enrolled: patients with OvCa who underwent a diagnostic or cytoreductive surgery and nononcological patients, who underwent abdominal surgery for benign gynecological conditions and acted as the control group. Systematic extraction of PFD-sEVs from surgical samples enabled us to observe significant quantitative and qualitative differences associated with cancer diagnosis, disease stage, and platinum chemosensitivity. Proteomic profiling of PFD-sEVs led to the identification of molecular pathways and proteins of interest and to the biological validation of S100A4 and STX5. In addition, unsupervised analysis of PFD-sEV proteomic profiles in high-grade serous ovarian carcinomas (HGSOCs) revealed 2 clusters with different outcomes in terms of overall survival. In conclusion, comprehensive characterization of PFD-sEV content provided a prognostic value with potential implications in HGSOC clinical management.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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