Abstract Objective Missense mutations in the proprotein convertase subtilisin/kexin type 9 gene ( PCSK 9) can cause familial hypercholesterolemia. However, two nonsense variants of PCSK9 , Y142X and C679X, found in ∼2% of black American subjects, are associated with a 28% reduction in mean low density lipoprotein (LDL)–cholesterol. We sought to determine the frequency and effect of these nonsense variants in an African population. Methods and results PCSK9 genotypes were determined in 653 black African women attending two antenatal clinics in Zimbabwe. C679X occurred in 3.7% of subjects and was associated with a 27% reduction in LDL–cholesterol (1.6 ± 0.3 mmol/L versus 2.2 ± 0.7 mmol/L in non-carriers). We did not observe the Y142X variant. Conclusions Our results show that the PCSK9 C679X variant has a marked cholesterol-lowering effect.