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Peters, LM; Fridell, RA; Boger, ET; San Agustin, TB; Madeo, AC; Griffith, AJ; Friedman, TB; Morell, RJ
Clinical genetics, April 2008, Letnik: 73, Številka: 4Journal Article
We ascertained a large North American family, LMG2, segregating progressive, non‐syndromic, sensorineural hearing loss. A genome‐wide scan identified significant evidence for linkage (maximum logarithm of the odds (LOD) score = 4.67 at θ = 0 for D4S398) to markers in a 5.7‐cM interval on chromosome 4q12‐13.1. The DFNA27 interval spans 8.85 Mb and includes at least 61 predicted and 8 known genes. We sequenced eight genes and excluded them as candidates for the DFNA27 gene.
