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Chi, Hao; Liu, Chao; Yang, Hao; Zeng, Wen-Feng; Wu, Long; Zhou, Wen-Jing; Wang, Rui-Min; Niu, Xiu-Nan; Ding, Yue-He; Zhang, Yao; Wang, Zhao-Wei; Chen, Zhen-Lin; Sun, Rui-Xiang; Liu, Tao; Tan, Guang-Ming; Dong, Meng-Qiu; Xu, Ping; Zhang, Pei-Heng; He, Si-Min
Nature biotechnology, 12/2018, Letnik: 36, Številka: 11Journal Article
We present a sequence-tag-based search engine, Open-pFind, to identify peptides in an ultra-large search space that includes coeluting peptides, unexpected modifications and digestions. Our method detects peptides with higher precision and speed than seven other search engines. Open-pFind identified 70-85% of the tandem mass spectra in four large-scale datasets and 14,064 proteins, each supported by at least two protein-unique peptides, in a human proteome dataset.
