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Piccioli, Patrizia; Balbi, Giuseppe; Serra, Martina; Morabito, Anna; Lamparelli, Teresa; Gobbi, Marco; Laurent, Stefania; Dozin, Beatrice; Bruzzi, Paolo; Ferraris, Anna Maria; Bacigalupo, Andrea; Notaro, Rosario; Pistillo, Maria Pia
Annals of hematology, 06/2010, Letnik: 89, Številka: 6Journal Article
Conflicting observations have been reported about the role of CTLA-4 gene polymorphisms in the clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT). We have investigated three polymorphisms of the CTLA-4 gene (−318C>T, +49A>G, CT60G>A) in 133 donor/recipient pairs who underwent HLA-matched sibling donor HSCT for hematological malignancies. We found no association of the clinical outcome of the HSCT with either recipient or donor −318C>T and CT60G>A polymorphisms. At variance, we found a significant association of donor +49A>G G/G genotype with longer overall survival (OS; log-rank test, P = 0.04), and the number of +49A>G G-alleles in the recipient with longer OS (P = 0.027), longer disease-free survival (P = 0.036) and reduced relapse rate (P = 0.042). However, only recipient +49A>G polymorphism was retained as independent prognostic factor in a multivariate analysis, suggesting that the expression of CTLA-4 on the cells of recipient may be relevant for the clinical outcome of HSCT.
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