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Wrobel, Antoni G; Benton, Donald J; Hussain, Saira; Harvey, Ruth; Martin, Stephen R; Roustan, Chloë; Rosenthal, Peter B; Skehel, John J; Gamblin, Steven J
Nature communications, 10/2020, Letnik: 11, Številka: 1Journal Article
The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.
