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Barker, Brianne R; Taxman, Debra J; Ting, Jenny P-Y
Current opinion in immunology, 10/2011, Letnik: 23, Številka: 5Journal Article
Highlights ► The IL-1β/IL-18-processing inflammasome is composed of an NLR sensor, Aim2 or RIG-I; the adaptor ASC/Pycard; and caspase-1. ► Many inflammasome components have roles in the transcriptional induction of non-inflammasome cytokines. ► Caspase-1 also is proposed to have a role in the processing of growth factors through the unconventional secretory pathway. ► Other cytokines may influence the inflammasome transcriptionally or via direct interaction with inflammasome components. ► This cross-regulation may lead to increased abilities for the cell to respond appropriately to diverse pathogen threats.
