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Shin, Joo-Ho; Ko, Han Seok; Kang, Hochul; Lee, Yunjong; Lee, Yun-Il; Pletinkova, Olga; Troconso, Juan C.; Dawson, Valina L.; Dawson, Ted M.
Cell, 03/2011, Letnik: 144, Številka: 5Journal Article
A hallmark of Parkinson's disease (PD) is the preferential loss of substantia nigra dopamine neurons. Here, we identify a new parkin interacting substrate, PARIS (ZNF746), whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human PD brain. PARIS represses the expression of the transcriptional coactivator, PGC-1α and the PGC-1α target gene, NRF-1 by binding to insulin response sequences in the PGC-1α promoter. Conditional knockout of parkin in adult animals leads to progressive loss of dopamine (DA) neurons in a PARIS-dependent manner. Moreover, overexpression of PARIS leads to the selective loss of DA neurons in the substantia nigra, and this is reversed by either parkin or PGC-1α coexpression. The identification of PARIS provides a molecular mechanism for neurodegeneration due to parkin inactivation. Display omitted Display omitted ► PARIS (ZNF746) is a substrate of the E3 ubiquitin ligase parkin ► PARIS accumulates in parkin inactivation models and in human Parkinson's disease brain ► PARIS transcriptionally represses PGC-1α by binding to insulin responsive sequences ► Degeneration of dopamine neurons in conditional parkin knockouts depends on PARIS
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