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Zhang, Xuesong; Xie, Haibo; Liu, Zhibing; Zhang, Jiaxiang; Deng, Lihua; Wu, Qifeng; Duan, Yuansheng; Wang, Feng; Wu, Changhao; Zhu, Qixing
Ecotoxicology and environmental safety, 07/2023, Letnik: 259Journal Article
More and more clinical evidence shows that occupational medicamentose-like dermatitis due to trichloroethylene (OMDT) patients often present immune kidney damage. However, the exact mechanisms of cell-to-cell transmission in TCE-induced immune kidney damage remain poorly understood. The present study aimed to explore the role of high mobility group box-1 (HMGB 1) in glomerular endothelial cell-podocyte transmission. 17 OMDT patients and 34 controls were enrolled in this study. We observed that OMDT patients had renal function injury, endothelial cell activation and podocyte injury, and these indicators were associated with serum HMGB 1. To gain mechanistic insight, a TCE-sensitized BALB/c mouse model was established under the interventions of sirtuin 1 (SIRT 1) activator SRT 1720 (0.1 ml, 5 mg/kg) and receptor for advanced glycation end products (RAGE) inhibitor FPS-ZM 1 (0.1 ml, 1.5 mg/kg). We identified HMGB 1 acetylation and its endothelial cytoplasmic translocation following TCE sensitization, but SRT 1720 abolished the process. RAGE was located on podocytes and co-precipitated with extracellular acetylated HMGB 1, promoting podocyte injury, while SRT 1720 and FPS-ZM 1 both alleviated podocyte injury. The results demonstrate that interventions to upstream and downstream pathways of HMGB 1 may weaken glomerular endothelial cell-podocyte transmission, thereby alleviating TCE-induced immune renal injury. Display omitted •HMGB1 were correlated with endothelial cell activation and podocyte injury in OMDT patients.•HMGB 1 exerted a bridging role on endothelial cell-podocyte transmission in TCE-induced renal injury.•SIRT1/HMGB1/RAGE axis involved in endothelial cell-podocyte transmission in TCE-induced renal injury.
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in: SICRIS
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