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Takeuchi, Fumihiko; Akiyama, Masato; Matoba, Nana; Katsuya, Tomohiro; Nakatochi, Masahiro; Tabara, Yasuharu; Narita, Akira; Saw, Woei-Yuh; Moon, Sanghoon; Spracklen, Cassandra N; Chai, Jin-Fang; Kim, Young-Jin; Zhang, Liang; Wang, Chaolong; Li, Huaixing; Li, Honglan; Wu, Jer-Yuarn; Dorajoo, Rajkumar; Nierenberg, Jovia L; Wang, Ya Xing; He, Jing; Bennett, Derrick A; Takahashi, Atsushi; Momozawa, Yukihide; Hirata, Makoto; Matsuda, Koichi; Rakugi, Hiromi; Nakashima, Eitaro; Isono, Masato; Shirota, Matsuyuki; Hozawa, Atsushi; Ichihara, Sahoko; Matsubara, Tatsuaki; Yamamoto, Ken; Kohara, Katsuhiko; Igase, Michiya; Han, Sohee; Gordon-Larsen, Penny; Huang, Wei; Lee, Nanette R; Adair, Linda S; Hwang, Mi Yeong; Lee, Juyoung; Chee, Miao Li; Sabanayagam, Charumathi; Zhao, Wanting; Liu, Jianjun; Reilly, Dermot F; Sun, Liang; Huo, Shaofeng; Edwards, Todd L; Long, Jirong; Chang, Li-Ching; Chen, Chien-Hsiun; Yuan, Jian-Min; Koh, Woon-Puay; Friedlander, Yechiel; Kelly, Tanika N; Bin Wei, Wen; Xu, Liang; Cai, Hui; Xiang, Yong-Bing; Lin, Kuang; Clarke, Robert; Walters, Robin G; Millwood, Iona Y; Li, Liming; Chambers, John C; Kooner, Jaspal S; Elliott, Paul; van der Harst, Pim; Chen, Zhengming; Sasaki, Makoto; Shu, Xiao-Ou; Jonas, Jost B; He, Jiang; Heng, Chew-Kiat; Chen, Yuan-Tsong; Zheng, Wei; Lin, Xu; Teo, Yik-Ying; Tai, E-Shyong; Cheng, Ching-Yu; Wong, Tien Yin; Sim, Xueling; Mohlke, Karen L; Yamamoto, Masayuki; Kim, Bong-Jo; Miki, Tetsuro; Nabika, Toru; Yokota, Mitsuhiro; Kamatani, Yoichiro; Kubo, Michiaki; Kato, Norihiro
Nature communications, 11/2018, Letnik: 9, Številka: 1Journal Article
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
