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de Miguel-Perez, Diego; Russo, Alessandro; Arrieta, Oscar; Ak, Murat; Barron, Feliciano; Gunasekaran, Muthukumar; Mamindla, Priyadarshini; Lara-Mejia, Luis; Peterson, Christine B; Er, Mehmet E; Peddagangireddy, Vishal; Buemi, Francesco; Cooper, Brandon; Manca, Paolo; Lapidus, Rena G; Hsia, Ru-Ching; Cardona, Andres F; Naing, Aung; Kaushal, Sunjay; Hirsch, Fred R; Mack, Philip C; Serrano, Maria Jose; Adamo, Vincenzo; Colen, Rivka R; Rolfo, Christian
Journal of experimental & clinical cancer research, 06/2022, Letnik: 41, Številka: 1Journal Article
Immune-checkpoint inhibitors (ICIs) changed the therapeutic landscape of patients with lung cancer. However, only a subset of them derived clinical benefit and evidenced the need to identify reliable predictive biomarkers. Liquid biopsy is the non-invasive and repeatable analysis of biological material in body fluids and a promising tool for cancer biomarkers discovery. In particular, there is growing evidence that extracellular vesicles (EVs) play an important role in tumor progression and in tumor-immune interactions. Thus, we evaluated whether extracellular vesicle PD-L1 expression could be used as a biomarker for prediction of durable treatment response and survival in patients with non-small cell lung cancer (NSCLC) undergoing treatment with ICIs. Dynamic changes in EV PD-L1 were analyzed in plasma samples collected before and at 9 ± 1 weeks during treatment in a retrospective and a prospective independent cohorts of 33 and 39 patients, respectively. As a result, an increase in EV PD-L1 was observed in non-responders in comparison to responders and was an independent biomarker for shorter progression-free survival and overall survival. To the contrary, tissue PD-L1 expression, the commonly used biomarker, was not predictive neither for durable response nor survival. These findings indicate that EV PD-L1 dynamics could be used to stratify patients with advanced NSCLC who would experience durable benefit from ICIs.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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