E-viri
Recenzirano
Odprti dostop
-
Aglago, Elom K; Cross, Amanda J; Riboli, Elio; Fedirko, Veronika; Hughes, David J; Fournier, Agnes; Jakszyn, Paula; Freisling, Heinz; Gunter, Marc J; Dahm, Christina C; Overvad, Kim; Tjønneland, Anne; Kyrø, Cecilie; Boutron-Ruault, Marie-Christine; Rothwell, Joseph A; Severi, Gianluca; Katzke, Verena; Srour, Bernard; Schulze, Matthias B; Wittenbecher, Clemens; Palli, Domenico; Sieri, Sabina; Pasanisi, Fabrizio; Tumino, Rosario; Ricceri, Fulvio; Bueno-de-Mesquita, Bas; Derksen, Jeroen W G; Skeie, Guri; Jensen, Torill Enget; Lukic, Marko; Sánchez, Maria-Jose; Amiano, Pilar; Colorado-Yohar, Sandra; Barricarte, Aurelio; Ericson, Ulrika; van Guelpen, Bethany; Papier, Keren; Knuppel, Anika; Casagrande, Corinne; Huybrechts, Inge; Heath, Alicia K; Tsilidis, Konstantinos K; Jenab, Mazda
British journal of cancer, 04/2023, Letnik: 128, Številka: 8Journal Article
Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive. We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox regression. We modelled substitution of a 1 mg/day of heme iron intake with non-heme iron using the leave one-out method. Of 450,105 participants (318,680 women) followed for 14.2 ± 4.0 years, 6162 (3511 women) developed CRC. In men, total iron intake was not associated with CRC risk (highest vs. lowest quintile, HR :0.88; 95%CI:0.73, 1.06). An inverse association was observed for non-heme iron (HR :0.80, 95%CI:0.67, 0.96) whereas heme iron showed a non-significant association (HR :1.10; 95%CI:0.96, 1.27). In women, CRC risk was not associated with intakes of total (HR :1.11, 95%CI:0.94, 1.31), heme (HR :0.95; 95%CI:0.84, 1.07) or non-heme iron (HR :1.03, 95%CI:0.88, 1.20). Substitution of heme with non-heme iron demonstrated lower CRC risk in men (HR:0.94; 95%CI: 0.89, 0.99). Our findings suggest potential sex-specific CRC risk associations for higher iron consumption that may differ by dietary sources.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.