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Weidenbacher, Payton A-B; Sanyal, Mrinmoy; Friedland, Natalia; Tang, Shaogeng; Arunachalam, Prabhu S; Hu, Mengyun; Kumru, Ozan S; Morris, Mary Kate; Fontenot, Jane; Shirreff, Lisa; Do, Jonathan; Cheng, Ya-Chen; Vasudevan, Gayathri; Feinberg, Mark B; Villinger, Francois J; Hanson, Carl; Joshi, Sangeeta B; Volkin, David B; Pulendran, Bali; Kim, Peter S
Nature communications, 04/2023, Letnik: 14, Številka: 1Journal Article
While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of concern (VOCs). Here, we describe DCFHP, a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), elicits potent and durable neutralizing antisera in non-human primates against known VOCs, including Omicron BQ.1, as well as against SARS-CoV-1. Following a booster ~one year after the initial immunization, DCFHP-alum elicits a robust anamnestic response. To enable global accessibility, we generated a cell line that can enable production of thousands of vaccine doses per liter of cell culture and show that DCFHP-alum maintains potency for at least 14 days at temperatures exceeding standard room temperature. DCFHP-alum has potential as a once-yearly (or less frequent) booster vaccine, and as a primary vaccine for pediatric use including in infants.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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