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  • Activation of NF-κB driven ...
    Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes
    Ping, Zhen; Chen, Si; Hermans, Sjoerd J F; Kenswil, Keane J G; Feyen, Jacqueline; van Dijk, Claire; Bindels, Eric M J; Mylona, Athina M; Adisty, Niken M; Hoogenboezem, Remco M; Sanders, Mathijs A; Cremers, Eline M P; Lindenbergh-Kortleve, Dicky J; Samsom, Janneke N; van de Loosdrecht, Arjan A; Raaijmakers, Marc H G P

    Leukemia, 02/2019, Letnik: 33, Številka: 2
    Journal Article

    HighlightsActivation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.

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