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Bos, Isabelle; Vos, Stephanie; Verhey, Frans; Scheltens, Philip; Teunissen, Charlotte; Engelborghs, Sebastiaan; Sleegers, Kristel; Frisoni, Giovanni; Blin, Olivier; Richardson, Jill C.; Bordet, Régis; Tsolaki, Magda; Popp, Julius; Peyratout, Gwendoline; Martinez-Lage, Pablo; Tainta, Mikel; Lleó, Alberto; Johannsen, Peter; Freund-Levi, Yvonne; Frölich, Lutz; Vandenberghe, Rik; Westwood, Sarah; Dobricic, Valerija; Barkhof, Frederik; Legido-Quigley, Cristina; Bertram, Lars; Lovestone, Simon; Streffer, Johannes; Andreasson, Ulf; Blennow, Kaj; Zetterberg, Henrik; Visser, Pieter Jelle
Alzheimer's & dementia, 20/May , Letnik: 15, Številka: 5Journal Article
We investigated relations between amyloid-β (Aβ) status, apolipoprotein E (APOE) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau). We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)-type dementia from the EMIF-AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL, YKL-40, and T-tau with Aβ status (Aβ− vs. Aβ+), clinical diagnosis APOE ε4 carriership, baseline cognition, and change in cognition. Ng and T-tau distinguished between Aβ+ from Aβ− individuals in each clinical group, whereas NFL and YKL-40 were associated with Aβ+ in nondemented individuals only. APOE ε4 carriership did not influence NFL, Ng, and YKL-40 in Aβ+ individuals. NFL was the best predictor of cognitive decline in Aβ+ individuals across the cognitive spectrum. Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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