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Chu, Hin; Hu, Bingjie; Huang, Xiner; Chai, Yue; Zhou, Dongyan; Wang, Yixin; Shuai, Huiping; Yang, Dong; Hou, Yuxin; Zhang, Xi; Yuen, Terrence Tsz-Tai; Cai, Jian-Piao; Zhang, Anna Jinxia; Zhou, Jie; Yuan, Shuofeng; To, Kelvin Kai-Wang; Chan, Ivy Hau-Yee; Sit, Ko-Yung; Foo, Dominic Chi-Chung; Wong, Ian Yu-Hong; Ng, Ada Tsui-Lin; Cheung, Tan To; Law, Simon Ying-Kit; Au, Wing-Kuk; Brindley, Melinda A; Chen, Zhiwei; Kok, Kin-Hang; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung
Nature communications, 01/2021, Letnik: 12, Številka: 1Journal Article
Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on SARS-CoV-2 transmissibility and pathogenesis, and reveal targets of intervention. Here, we analyze host and viral determinants essential for efficient SARS-CoV-2 infection in both human lung epithelial cells and ex vivo human lung tissues. We identify heparan sulfate as an important attachment factor for SARS-CoV-2 infection. Next, we show that sialic acids present on ACE2 prevent efficient spike/ACE2-interaction. While SARS-CoV infection is substantially limited by the sialic acid-mediated restriction in both human lung epithelial cells and ex vivo human lung tissues, infection by SARS-CoV-2 is limited to a lesser extent. We further demonstrate that the furin-like cleavage site in SARS-CoV-2 spike is required for efficient virus replication in human lung but not intestinal tissues. These findings provide insights on the efficient SARS-CoV-2 infection of human lungs.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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