E-viri
Recenzirano
Odprti dostop
-
Paximadas, Dimitrios; Trembling, Paul; Heneghan, Michael A.; Neuberger, James M.; Hirschfield, Gideon M.; Sandford, Richard N.; Mells, George F.; Alexander, Graeme; Sandford, Richard; Taylor‐Robinson, Simon; Czajkowski, Marek; Gyawali, Pranab; Marley, Richard; Foster, Graham; Subhani, Javaid; Gasem, Jaber; Mathialahan, Thiriloganathan; Shorrock, Christopher; Lipscomb, George; Tibble, Jeremy; Gorard, David; Dawwas, Mohamed; Mitchison, Harriet; Sayer, Joanna; Hankey, Lorraine; Koss, Konrad; Brown, Jonathan; Gordon, Harriet; Salam, Imroz; Narain, Mark; Taylor‐Robinson, Simon; Grellier, Leonie; Das, Debashis; Jones, Rebecca; Bird, George; Kitchen, Paul; Yoong, Kevin; MacFaul, George; Fraser, Andrew; Dillon, John; Shmueli, Udi; Naqvi, Asifabbas; Lee, Tom; Ryder, Stephen D.; Sharer, Nicholas; Aspinall, Richard; Hussaini, Hyder; Ayres, Reuben; Marshall, Eileen; Butterworth, Jeff; Shearman, Jeremy; Bray, Gary; Das, Debashis; Wright, Mark; Collins, Carole; Whalley, Simon; Li, Andy; Wong, Voi Shim; Ransford, Rupert; Millson, Charles; Harrison, Melanie; Mulvaney‐Jones, Caroline; Loftus, Alison; Damant, Rose; Desousa, Phillipa; McKay, Alexandra; Tan, LaiTing; Flahive, Kerry; Ford, Chris; MacNicol, Carolyn; Wilkins, Joy; Young, Karin; Martin, Kirsty; Tanqueray, Elizabeth; Morrison, Jennifer; Slininger, Susan; Ainsworth, Mark; Lord, Susan; Longhurst, Beverley; Hayes, Maria; Shpuza, Ervin; Gunter, Emma; Dewhurst, Hannah; Leoni, Marina; Tyrer, David; Dali‐kemmery, Lola; Lambourne, Victoria; Shinder, Bal; Mills, Marisa; Brown, Carly; Archer, Emily; Mupudzi, Mcdonald; Batham, Sally; Conder, Jill; Orpe, Jacky; Currie, Lynn; Amey, Isobel; Cumlat, Lourdes; Winter, Louise; Sweeting, Helen
Hepatology (Baltimore, Md.), March 2016, Letnik: 63, Številka: 3Journal Article
The biochemical response to ursodeoxycholic acid (UDCA)—so‐called “treatment response”—strongly predicts long‐term outcome in primary biliary cholangitis (PBC). Several long‐term prognostic models based solely on the treatment response have been developed that are widely used to risk stratify PBC patients and guide their management. However, they do not take other prognostic variables into account, such as the stage of the liver disease. We sought to improve existing long‐term prognostic models of PBC using data from the UK‐PBC Research Cohort. We performed Cox's proportional hazards regression analysis of diverse explanatory variables in a derivation cohort of 1,916 UDCA‐treated participants. We used nonautomatic backward selection to derive the best‐fitting Cox model, from which we derived a multivariable fractional polynomial model. We combined linear predictors and baseline survivor functions in equations to score the risk of a liver transplant or liver‐related death occurring within 5, 10, or 15 years. We validated these risk scores in an independent cohort of 1,249 UDCA‐treated participants. The best‐fitting model consisted of the baseline albumin and platelet count, as well as the bilirubin, transaminases, and alkaline phosphatase, after 12 months of UDCA. In the validation cohort, the 5‐, 10‐, and 15‐year risk scores were highly accurate (areas under the curve: >0.90). Conclusions: The prognosis of PBC patients can be accurately evaluated using the UK‐PBC risk scores. They may be used to identify high‐risk patients for closer monitoring and second‐line therapies, as well as low‐risk patients who could potentially be followed up in primary care. (Hepatology 2016;63:930–950)
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.