This study investigated the physicochemical properties of the interaction of indomethacin and copper chloride using the electrical conductance measurement in methanol, ethanol, and their binary mixture with water at room temperature (298.15 K), to determine the solvation behavior, redox behavior, and kinetics. The association parameters were computed using the Fuoss-Hsia-Fernández-Prini and Fuoss-Shedlovsky models. The standard Gibbs energy for association (ΔGoA), Walden product (Λoηo), and hydrodynamic radii (RH) were calculated to study the interaction of indomethacin and copper chloride. On the other hand, cyclic voltammetry examines the electrochemical redox behavior of copper chloride using a gold electrode and its interactions with indomethacin. Results showed changes in peak potentials and currents density in the presence of indomethacin, indicating alterations in redox behavior and reaction rates. Overall, this research can be valuable in understanding the electrochemical properties and potential applications of indomethacin and copper chloride, as well as in developing new drugs or therapeutic agents, which could have has implications in various fields, including drug development, electrochemistry, and materials science. •The study investigated the physicochemical properties of the interaction between indomethacin and copper chloride.•The electrical conductance in different solvents was determined to provide information about the solvation behavior, redox behavior, and kinetics of the system using the Fuoss-Shedlovsky and Fuoss-Hsia-Fernández-Prini models.•The cyclic voltammetry study revealed changes in the electrochemical redox behavior of CuCl2 in the presence of indomethacin, indicating potential applications in drug development and materials science.•Overall, this research can have significant implications in various fields.