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Bello, Gonzalo; Nacher, Mathieu; Divino, Flavia; Darcissac, Edith; Mir, Daiana; Lacoste, Vincent
Frontiers in microbiology, 07/2018, Letnik: 9Journal Article
The HIV-1 subtype B epidemic in French Guiana and Suriname is characterized by the co-circulation of the globally disseminated "B " lineage and of non-pandemic subtype B lineages of Caribbean origin (B ). To reconstruct the spatiotemporal pattern of spread of those viral lineages circulating in these two countries, a total of 361 HIV-1 subtype B sequences recovered from treatment-naive adult patients from French Guiana and Suriname between 2006 and 2012 were combined with B and B reference sequences. Major Guianese/Surinamese B and B lineages were identified by Maximum Likelihood phylogenetic analysis and the spatiotemporal and demographic parameters estimated using a Bayesian coalescent-based method. We detected four B and three B transmission chains of large size that together comprise most pandemic and non-pandemic subtype B sequences from French Guiana (≥52%) and Suriname (≥70%) here analyzed. These major lineages were probably introduced into French Guiana and Suriname from the Caribbean (B ) and North/South America (B ) between the middle 1970s and the late 1980s and spread among populations from both countries with roughly comparable demographic growth rates. We detected a significant trend for higher viral loads and higher proportion of homosexual/bisexual men among subjects infected with B relative to B strains in French Guiana. These results show that the HIV subtype B epidemic in French Guiana and Suriname has been driven by multiple active B and B transmission chains that arose since the middle 1970s onward and operate in both countries simultaneously. Although no significant differences in the epidemic potential of major B and B lineages were observed, relevant associations between the infecting subtype B lineage and epidemiological and clinical characteristics were detected in French Guiana.
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in: SICRIS
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