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Cao, Jian-Kang; Cao, Tian-Zheng; Yue, Qian-Wen; Ma, Ying; Yang, Chuan-Ming; Zhang, Hong-Xi; Li, Ya-Chen; Dong, Qiao-Ke; Zhu, Yan-Ping; Sun, Yuan-Yuan
Molecules (Basel, Switzerland), 03/2024, Letnik: 29, Številka: 6Journal Article
A practical metal-free and additive-free approach for the synthesis of 6/7/8-membered oxacyclic ketone-fused isoxazoles/isoxazolines tetracyclic or tricyclic structures is reported through C -H bond radical nitrile oxidation and the intramolecular cycloaddition of alkenyl/alkynyl-substituted aryl methyl ketones. This convenient approach enables the simultaneous formation of isoxazole/isoxazoline and 6/7/8-membered oxacyclic ketones to form polycyclic architectures by using -butyl nitrite (TBN) as a non-metallic radical initiator and N-O fragment donor.
