E-viri
Recenzirano
Odprti dostop
-
Cortellini, Alessio; Ricciuti, Biagio; Tiseo, Marcello; Bria, Emilio; Banna, Giuseppe L; Aerts, Joachim GJV; Barbieri, Fausto; Giusti, Raffaele; Cortinovis, Diego L; Migliorino, Maria R; Catino, Annamaria; Passiglia, Francesco; Torniai, Mariangela; Morabito, Alessandro; Genova, Carlo; Mazzoni, Francesca; Di Noia, Vincenzo; Signorelli, Diego; Gelibter, Alain; Occhipinti, Mario Alberto; Rastelli, Francesca; Chiari, Rita; Rocco, Danilo; Inno, Alessandro; De Tursi, Michele; Di Marino, Pietro; Mansueto, Giovanni; Zoratto, Federica; Grossi, Francesco; Filetti, Marco; Pizzutilo, Pamela; Russano, Marco; Citarella, Fabrizio; Cantini, Luca; Targato, Giada; Nigro, Olga; Ferrara, Miriam G; Buti, Sebastiano; Scodes, Simona; Landi, Lorenza; Guaitoli, Giorgia; Della Gravara, Luigi; Tabbò, Fabrizio; Ricciardi, Serena; De Toma, Alessandro; Friedlaender, Alex; Petrelli, Fausto; Addeo, Alfredo; Porzio, Giampiero; Ficorella, Corrado
Journal for immunotherapy of cancer, 10/2020, Letnik: 8, Številka: 2Journal Article
BackgroundThe association between obesity and outcomes in patients receiving programmed death-1/programmed death ligand-1 (PD-L1) checkpoint inhibitors has already been confirmed in pre-treated non-small cell lung cancer (NSCLC) patients, regardless of PD-L1 tumor expression.MethodsWe present the outcomes analysis according to baseline body mass index (BMI) and BMI variation in a large cohort of metastatic NSCLC patients with a PD-L1 expression ≥50%, receiving first line pembrolizumab. We also evaluated a control cohort of metastatic NSCLC patients treated with first line platinum-based chemotherapy. Normal weight was set as control group.Results962 patients and 426 patients were included in the pembrolizumab and chemotherapy cohorts, respectively. Obese patients had a significantly higher objective response rate (ORR) (OR=1.61 (95% CI: 1.04–2.50)) in the pembrolizumab cohort, while overweight patients had a significantly lower ORR (OR=0.59 (95% CI: 0.37–0.92)) within the chemotherapy cohort. Obese patients had a significantly longer progression-free survival (PFS) (HR=0.61 (95% CI: 0.45–0.82)) in the pembrolizumab cohort. Conversely, they had a significantly shorter PFS in the chemotherapy cohort (HR=1.27 (95% CI: 1.01–1.60)). Obese patients had a significantly longer overall survival (OS) within the pembrolizumab cohort (HR=0.70 (95% CI: 0.49–0.99)), while no significant differences according to baseline BMI were found in the chemotherapy cohort. BMI variation significantly affected ORR, PFS and OS in both the pembrolizumab and the chemotherapy cohorts.ConclusionsBaseline obesity is associated to significantly improved ORR, PFS and OS in metastatic NSCLC patients with a PD-L1 expression of ≥50%, receiving first line pembrolizumab, but not among patients treated with chemotherapy. BMI variation is also significantly related to clinical outcomes.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.